The Epidemiology, Pathogenesis, and Treatment of Type 1 Diabetes Mellitus

Ishita Aggarwal, University of Toronto

Full manuscript:

Abstract: Type 1 diabetes mellitus(T1DM), also known as insulin-dependent diabetes, is a chronic disease caused by autoimmune(type 1a) or spontaneous(type 1b) destruction of pancreatic beta cells, resulting in insulin deficiency. It is generally diagnosed in children before 20 years of age and is oftentimes fatal. This review will discuss the epidemiology of T1DM, including its incidence and prevalence, related temporal trends and risk factors for development. Furthermore, pathogenesis and immune system involvement of the disease will be evaluated, with a particular focus on cells of the adaptive and innate immune systems. Finally, an overview of past, present and future treatments for T1DM will be discussed.

Read the full manuscript: