Neural Control of Micturition in a Rat Model of Parkinson’s Disease

Natalie Poonam Phagu, Stony Brook University

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Abstract: Parkinson’s Disease (PD) is a neural disorder characterized by atypical motor function as well as dysfunction of the lower urinary tract (LUT). Micturition (urine evacuation/voiding) and continence (urine storage) are modulated by the neurotransmitter dopamine (DA) through innervation in the Basal Ganglia region of the midbrain, including the substantia nigra pars compacta (SN). Loss of these dopaminergic pathways and the resultant loss of D1 receptor-mediated inhibition have been linked to the development of LUT dysfunction in PD (Araki et al, 2000 and Ogawa et al, 2006). Thus, through lesioning of the SN via 6-OHDA, this study has created a commonly used rat model of PD for the purpose of improving upon cystometric study and evaluation of bladder dysfunction in PD.

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